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These approaches encompass systemic administration of lactate-enriched solutions to provide metabolic support, as well as interventions aimed at inhibiting lactate production or transport as well as promoting its depletion to disrupt metabolic symbiosis in tumors, highlighting the dual therapeutic potential of lactate (150,151)

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Biliverdin reductase-A impairment links brain insulin resistance with increased Abeta production in an animal model of aging: implications for Alzheimer disease

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The present study also explores the possibility that the oxidized inactive form of e-GST may be present in blood, given that two critical cysteines, Cys47 and Cys101 (the latter corresponding to Cys103 in pig e-GST) are strictly conserved in all mammals tested, and that they form a disulfide both in vivo and in vitro as proved for the human enzyme