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These IDH1/2 mutations result in a gain of function reducing of -ketoglutarate to 2-hydroxyglutarate (2-HG), a competitive inhibitor of KG-dependent dioxygenases like TETs

Together, these nutrients may contribute to a healthier cardiovascular profile

[DOI] [PubMed] [Google Scholar] 73.Janson B.J., Alward W.L., Kwon Y.H., Bettis D.I., Fingert J.H., Provencher L.M., Goins K.M., Wagoner M.D., Greiner M.A

doi: 10.1016/j.mehy.2006.01.032

Newer measurement methods such as Magnetic Resonance Spectroscopy (MRS) and Positron Emission Tomography (PET) are less invasive and more cost-effective and show potential to be more accurate, but more research is needed to further validate and standardize results (Murray et al., 2024