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Furthermore, recent studies showed that the activation of multiple signaling pathways, such as phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt), protein kinase C (PKC), and mitogen-activated protein kinase (MAPK), facilitates the release of Nrf2 from Keap1 and subsequent translocation for the induction of various antioxidant and detoxification enzyme expressions [19, 38, 39]
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doi: 10.1016/j.jnutbio.2008.10.004
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[DOI] [PMC free article] [PubMed] [Google Scholar] 74.Perna F., Parekh S., Diorio C., Smith M., Subklewe M., Mehta R., Locke F.L., Shah N.N
