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10.1016/j.mam.2020.100924 27 FanJ.DuanL.WuN.XuX.XinJ.JiangS.et al (2020)

Proper cycling with planned off periods helps maintain sensitivity to the compound and supports long-term success

doi: 10.1016/j.neuro.2013.05.016

These fluid markers can be sampled longitudinally with minimal invasiveness, and combining them with TSPO-PET or other microglial/astrocytic imaging readouts yields a multimodal profile that better characterizes active neuroinflammatory states and may inform anti-inflammatory or disease-modifying treatment strategies (145)

the individual preparations are preferred when researchers need independent dose-response curves on each compound
As prepared GSH-AuNCs are extremely hydrophilic and thus it is clear that surface hydrophobication of these nanoclusters is required for their efficient encapsulation into PLGA nanoparticles
