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Moisture can lead to peptide hydrolysis and degradation

In this study of FM/chronic fatigue syndrome, patients who were good responders were found to be using a higher and more frequent doses of vitamin B12 for a longer period [17]

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However, large-scale human clinical trials remain limited

Modern Nutrition in Health and Disease

In contrast, the tenfold increase in vitamin D (7.5 to 75 g) did not consistently result in higher serum vitamin D concentrations in the Optimum 2.0 group throughout follow-up