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Should the RRCT be a feasible option for a given registry and for a clinical questions, careful delineation of responsibilities regarding randomisation, missing data, handling of data queries, data quality, data extraction and management of serious adverse event information need to be considered

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AMPK and activation of macrophages and DCs Finally, LPS also decreases activation of the energy-sensing enzyme AMP-activated protein kinase (AMPK) in macrophages 62