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This might vary from the occurrence of ballooning (vacuolar) degeneration, characterized by inflated cells with clear cytoplasm, to necrosis, which refers to the death of cells

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these typically decrease over time

doi: 10.1038/clpt.1985.17

There are 9 NER functioning proteins that can lead to premature skin aging when experiencing deficiencies (Panich et al., 2016)

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