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Glutathione is more than just a small tripeptideits a vital tool for life and research alike

For detailed information on the importance of glutathione and causes of deficiency see our blog What is Glutathione and Why Do We Need It

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Here we investigated the possibility of correcting this defective NOS activity by supplementation with the cofactor tetrahydrobiopterin, BH4

If our data based on an intense and short exposure to HNE can be extended to an in vivo situation where low concentrations of HNE are produced on a long time scale, the present results suggest that although the amount of DNA adducts is low upon treatment by exogenous HNE, their formation could be favored upon oxidative stress