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Doses of 4 mg/kg/day (approximately 150 times the maximum recommended human dose) administered during the period of organogenesis in the rabbit caused an increased occurrence of various malformations

Prevention focuses on sun protection, early identification, and vigilant monitoring

Androgen-stimulated pubertal growth: the effects of testosterone and dihydrotestosterone on growth hormone and insulin-like growth factor-I in the treatment of short stature and delayed puberty

Thermoscopic findings include asymmetric perifollicular pigmentation, homo genius areas with obliteration of follicular openings, increased vascularity, red or dark rhomboidal structures, annular granular pattern, gray dots and slate gray globules

Increased melanin production is seen in conditions where adrenocorticotropic hormone (ACTH) is elevated, such as Addison's and Cushing's disease