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Risks from Concomitant Use with Benzodiazepines or Other CNS Depressants Profound sedation, respiratory depression, coma, and death may result from the concomitant use of oxycodone and acetaminophen tablets with benzodiazepines and/or other CNS depressants, including alcohol (e.g., non-benzodiazepine sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, gabapentinoids, [gabapentin or pregabalin] and other opioids)

This decrease in repair capacity could explain the increased prevalence of old people for skin cancer

However, long-term human safety data is still being established

M., Ward, L

12 World Health OrganizationFood and Agriculture Organization of the United Nations

Lu ZF, Doulabi BZ, Wuisman PI, Bank RA, Helder MN