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[115] reported the TPC activity in catechin eq/g, whereas Handa et al

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10.3389/fnagi.2010.00012 205 WangX.PalR.ChenX

PD patients are also associated with non-motor symptoms such as depression, dementia, sleep difficulties, autonomic failures and pain, in which to date the exact mechanism of pain and its modulation is unclear

Additionally, HDAC6 inhibitors activate redox-regulating proteins like peroxiredoxins (reduce ROS) and support the function of the autophagy and ubiquitin-proteasome system (UPS) (both are impaired in PD patients) 62