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Yang and colleagues observed significantly higher levels of IL1, TNF, and IL6 in the brain tissue of mice with combined TBI and bone fracture compared to those with TBI alone at 4 days postinjury [314]

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Figure 2 The core characteristics and mechanisms of candidalysin are well-defined: it exerts cytotoxicity by membrane insertion/lytication, activates pathways such as EGFR-MAPK and NLRP3 inflammasome to induce inflammation and damage in host cells, and targeted anti-infection strategies against this toxin have been summarized (Lortal et al., 2025)

Monitoring oxidative stress products can offer valuable insights into the development of AD and highlight essential clinical and therapeutic effects

Many inflammatory mechanisms are themselves capable of injuring host tissuesfor example, free radicals, various hydrolases, cationic proteins, and disturbances of oxygen transport resulting from inflammatory microcirculation. Consequently, an anti-inflammatory resolving response forms during inflammation, which limits both the intensity and the duration of the inflammatory reaction [816,817]

Gly-His-Lys (GHK) copper(II) complex