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Among them, mutations such as p.Lys44Glu and p.Glu320Gln in the SLC19A3 gene can manifest as WerNicke-like encephalopathy [59,60,61]
However, numerous trials, especially in Phase II and III, have failed to achieve their primary endpoints (Liu et al., 2022a
In vitro and in vivo research has demonstrated their anticancer properties, including decreased tumor occurrence, growth suppression, and improved antioxidant activity
[The "big heart" of carnitine]
These findings also generalise to opioid-induced dopamine release [336,339]
doi: 10.1016/j.ijpsycho.2016.05.010
