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Pretreatment with 10 g/g GHK-Cu significantly reduced the phosphorylation of both NF-B p65 and p38 MAPK, and slightly decreased JNK1/2 phosphorylation, with no effect on ERK1/2

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Failure of DNA repair induces apoptosis through p53 activation, mitochondrial pathway induction, and persistent DNA damage response (DDR) signaling 8-10

The severity and duration of deficiency are perhaps the most significant factors

They can cause significant muscle loss along with fat loss, which some research suggests may be as high as 30-40% of total weight lost

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