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Your health care provider needs to know if you have any of these conditions: kidney disease

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in vivo studies (animal models): It's absolutely paramount to consult existing scientific literature, particularly peer-reviewed articles, specific to your chosen model and research question

That said, if any adverse effect is suspected to be dose-related, the dose can be reduced

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For those looking to buy Vitamin B12, understanding the need for refrigeration and appropriate storage conditions is as important as the injection itself