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Description
To generate DIDO and RBM15 SPOC-deleted cell lines, two gRNAs targeting the flanking region of the SPOC domain (DIDO: 5-GGGTCGTGTCTCCCTCTGGA-3 and 5-CCAAGAATTATATTCGGACG-3

However, comprehensive human pharmacokinetic data remain limited, underscoring reliance on standardized extracts such as SHR-5 with defined rosavin-to-salidroside ratios (99, 101, 102)

[DOI] [PMC free article] [PubMed] [Google Scholar] Zitka O., Skalickova S., Gumulec J., Masarik M., Adam V., Hubalek J., Trnkova L., Kruseova J., Eckschlager T., Kizek R

Association of sleep duration in middle and old age with incidence of dementia

This regulatory response was absent in adult mice (Yu and Zhao, 2023), highlighting age-dependent variations in systemic Mn regulation that should be considered in future studies
F.et al (2025)
