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Potential of Dietary Hemp and Cannabinoids to Modulate Immune Response to Enhance Health and Performance in Animals: Opportunities and Challenges. Frontiers in Immunology 14: 1285052

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These compositional shifts elevate SCFAs such as butyrate and propionate, which activate G-protein-coupled receptors free fatty acid receptor 2 (FFAR2) and free fatty acid receptor 3 (FFAR3) and inhibit histone deacetylases, reducing pro-inflammatory cytokine expression

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Mn-induced NF-B activation through NOS2 expression confirms its role in oxidative stress (285).While direct evidence for IL-12, IL-18, and CCL2 regulation is limited, NF-B likely influences their expression indirectly, with CCL2 upregulation closely linked to NF-B activation (286)