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By contrast, hesperetin inhibits ferritinophagy and mitigates ferroptosis by modulating the PI3K/AKT/mTOR/ULK1 pathway (100), further underscoring the context-dependent role of ULK1

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In this model, endogenous glutamine production is not sufficient to counteract GSH depletion due to oxidative stress, and exogenous administration attenuates GSH depletion and MDA levels [111]

81 Real-time qPCR was performed with TB green reagent (Takara) using qPCR equipment (LightCycler96, Roche), and NADPH as a housekeeping gene

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