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It acts as a cofactor for enzymes that stabilize and crosslink collagen fibers, and it promotes the expression of genes that build collagen

FEBS Lett 32(1):132134 Gzer A, Bahan O, Gkek , Kaya U, Uyank G, Doruer G (2023) Short-term effects of ovariohysterectomy on some antioxidant parameters in cats

A randomized controlled trial of metformin on left ventricular hypertrophy in patients with coronary artery disease without diabetes: the MET-REMODEL trial

B12-50 g/kg

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In the GARNET study, 104 patients with EC who had progressed after at least 1 line of chemotherapy were treated with dostarlimab, a PD-1 inhibitor, with an ORR of 42.3%, disease control rate (DCR) of 57.7%, and mPFS of 8.1 months (95% CI 3.018)