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141,142 Thus, a number of authors have examined the possibility that metformin might be the cause of a vitamin B 12 deficiency and subsequently directly responsible for peripheral neuropathy in T2DM patients

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Taking the stomach minute lesions presentation as the outcome, we offer novel evidence for how cytoprotection/adaptive cytoprotection instantly functions in the stomach from tongue (first target), and then esophagus-stomach-duodenum chain of events, and impaired lower esophageal and pyloric sphincter