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10.1038/s41419-018-1029-4 31 YaoG.ZhangH.DengC.LuH.ZhangX.YangP

Ravikumar et al., 2010) reveal abnormal cleavage of PICALM in AD brains, with significantly reduced 75 kDa PICALM levels, disrupted cathepsin D (Cath D) processing, and impaired lysosomal function, leading to autophagy deficits and inhibited Tau degradation

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In contrast, in mice, the activation of LH glutamatergic neurons inhibits food intake, while their inhibition promotes food intake [10]

A nested case-control study in the prospective prostate cancer screening trial was conducted to examine the associations between IGF1/IGFBP3 levels and the risk of prostate cancer, in this trial, a total of 727 incident prostate cancer cases and 887 matched controls were selected for analyses, the result indicated that the bioavailability of IGF1 was associated with risk for aggressive prostate cancer in obese men (Weiss et al., 2007)

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