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Abstract PD7-05: A first-in-human phase I study to evaluate the oral selective estrogen receptor degrader (SERD), GDC-9545, in postmenopausal women with estrogen receptor-positive (ER+) HER2-negative (HER2-) metastatic breast cancer

Wan, C.-X

Controlled preparation of MnO2 hierarchical hollow nanostructures and their application in water treatment

This reduction in lipotoxic intermediates can alleviate hepatocellular stress, diminish inflammatory responses, and impede the activation of hepatic stellate cells, which are central to fibrogenesis [113,114]

Complex I is particularly interesting since glutathionylation occurs only at the 75 and 51 kDa subunits

Elevated glucose levels intensify oxidative stress through the upregulation of ROS production via multiple pathways including polyol, PKC, AGE/RAGE, and hexosamine pathways