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Lancet 289(7500):11261128 Angulo G, Zeleznjak J, Martnez-Vicente P, Puet-Ortiz J, Hengel H, Messerle M, Oxenius A, Jonjic S, Krmpotic A, Engel P et al (2021) Cytomegalovirus restricts icosl expression on antigen-presenting cells disabling T cell co-stimulation and contributing to immune evasion

Its canonical anti-inflammatory pathway contrasts with context-specific or biased signaling mechanisms that can contribute to either tumor suppression or promotion, highlighting the critical need to understand these nuances when considering TGR5 as a therapeutic target