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PMID 37749875

10.1001/jama.2019.15781 58 EttingerB.BlackD

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The study showed that there was a trend towards raised VEGF in all stages of varicose veins, but this only reached statistical significance in those with healed ulceration

A single-center, double-blinded, randomized controlled study to evaluate the relative efficacy of sublingual and oral vitamin B-complex administration in reducing total serum homocysteine levels

These elements support the relation between this condition and systemic inflammation, due to the ethanol-mediated activation of nuclear factor-B (NF-B) signaling pathway, which could alter gut barrier integrity, increasing portal and systemic endotoxemia