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Recent work proposes that the level of dormancy of the persisters is function of the level of stress undergone, the most extreme expression being the viable but non-cultivable bacteria [VBNC (Peyrusson et al., 2022), reviewed in ( This mini-review is centered on the works performed in condition of infections

The engineered NPs extend their in vivo half-life and improve their bioavailability and accumulation in the brain to treat the symptoms of PD

Targeting metabolism to sensitize standard therapies Altered metabolism engenders vulnerabilities that can be exploited to enhance the efficacy of conventional therapies, including chemotherapy, radiotherapy and targeted agents [143]

Once astrocytes become reactive, their ability to mitigate oxidative stress diminishes, and they may actively contribute to redox imbalance

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By identifying and treating low brain folate early, significant improvements in cognition, speech, motor function, and neurological health can be achieved