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Most of these studies were conducted exclusively in male rodents

Cells producing and secreting enteroglucagon were originally identified by immunohistochemistry with glucagon antibodies and it was noted that the cells in the gut mucosa differed from islet -cells that produce glucagon (42)

This is a good checkpoint for assessing whether to continue the current protocol, adjust doses, or add complementary compounds

Of note, exendin-4 was serendipitously discovered in the saliva of the Gila monster ( Heloderma suspectum ) and was revealed to be a GLP-1 analog that is resistant to DPP-4 action in 1992, even before the mechanism of GLP-1 degradation was identified [7]
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In the LEAD-5 trial, liraglutide was compared with insulin glargine in patients with background metformin and/or sulfonylurea therapies
