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Analgesic effects of the selective group II (mGlu2/3) metabotropic glutamate receptoragonists LY379268 and LY389795 in persistent and inflammatory pain models after acute and repeated dosing.Neuropharmacol 2005

Otros sntomas menos comnmente reconocidos como efecto neurotxico de estos tratamientos son el fenmeno de Lhermitte, caracterstico en pacientes tratados con platinos88 y el prurito, descrito con el paclitaxel9

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ERK, extracellular regulated kinase

doi: 10.26355/eurrev_202207_29212

The intramuscular administration could allow reaching high concentrations of ALC in the central nervous system, an essential condition for activating and boosting the epigenetic mechanisms underlying the analgesic action of the drug