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Thermal hyperalgesia was evaluated using the Hargreaves test, which measures paw withdrawal latency (PWL) in response to a focused infrared (IR) heat source applied to the plantar surface of the hind paw

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However, preliminary results suggest that high doses of NAC, still within therapeutic margins, do not limit but increase oxidative stress in the cochlea after treatment with ototoxic drugs, which share oxidative stress-related pathogenic pathways with NIHL

In the central nervous system, mitochondria in neurons and astrocytes are key sources of ROS, which help fine-tune neurotransmitter release, long-term potentiation, and cognitive functions like learning and memory (Massaad and Klann, 2011)

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