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Additionally, environmental influences such as obesity, gut microbiota imbalance, virus infection, and smoking contribute to increased risks of developing MS, with EpsteinBarr virus (EBV) infection increasing the risk by 32-fold [14]

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therefore, caution must be exerted when using baclofen in patients with renal insufficiency, and liver function tests should be checked before initiation of treatment and periodically thereafter (101)

New blisters may appear for up to a week, but a few days after appearing they become yellowish in colour, flatten and dry out

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