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This drawback can be due to only one side of the NO-system employed in the studies (i.e., decreased function by L-NAME application) while the other part remained unchecked (i.e., over-increased function by L-arginine, and vice versa) [124,125]

[DOI] [PMC free article] [PubMed] [Google Scholar] 252.Salmon AH, Ferguson JK, Burford JL, Gevorgyan H, Nakano D, Harper SJ, Bates DO, and Peti-Peterdi J

Using a streptozotocin-induced diabetic mouse model, the researchers demonstrated that systemic administration of BHB, an endogenous HCAR2 ligand, significantly reduced retinal endoplasmic reticulum (ER) stress and NLRP3 inflammasome activation, both of which are key contributors to diabetic retinopathy

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In this area, GM (cortex, anterior cingulate cortex) and WM (corpus callosum, cingulum, external capsule) regions were affected by both genotype and cuprizone