can b12 injection cause headache Headaches After Vitamin Shots: Causes & Solutions I've had a migraine since
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Metabolic pathways: B12 is a cofactor in two critical reactions: Methylmalonyl-CoA mutase: Converts methylmalonyl CoA (from odd-chain fatty acids and some amino acids) into succinyl-CoA, which enters the Krebs (TCA) cycle to make ATP (cellular energy)
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Both appear in research and practitioner protocols
