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This is followed by p-DRP1 oligomerization 8 and consequent hydrolysis of GTP by active DRP1 providing the mechanicenzymatic force by which fission occurs 9

This disrupts the anti-ferroptosis system in mitochondria, resulting in significant mitochondrial lipid peroxidation and ferroptosis [72]

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Following proxidant injections, plasma peroxide levels were increased within 1 h and returned to baseline within 24h