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doi: 10.1021/acsnano.9b00892

Specific combinations, such as docetaxel and trametinib, have been investigated in KRAS G12C cases with TP53 co-mutations, which did not improve the treatment efficacy in KRAS-mutant patients, highlighting the challenge for tailored co-mutation-targeted therapies [198]

Compared with -glucuronidase-based systems, -galactosidase-cleavable linkers are generally considered to favor intracellular activation, offering a release profile that may enable more controlled drug liberation with reduced reliance on extracellular bystander effects

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During a protracted use, a tolerance to analgesic effect develops resulting in a reduction of the effectiveness