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Elevated serum copper levels are often observed in these patients due to the release of copper-containing enzymes after myocardial injury or because sympathetic nerves promote the release of copper from liver stores into the bloodstream during stress (54)

[DOI] [PMC free article] [PubMed] [Google Scholar] Florez JC, Jablonski KA, Bayley N, Pollin TI, de Bakker PI, Shuldiner AR, Knowler WC, Nathan DM, Altshuler D

J Clin Oncol 35:440-445, 2017 [DOI] [PMC free article] [PubMed] [Google Scholar] 4.Kushner BH, Budnick A, Kramer K, et al

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Therefore, this purification and refolding strategy for SRCRD expressed in supernatants is not adequately effective

As already mentioned, these compounds may also exert their antioxidant activity indirectly, either through the capacity of recycling endogenous antioxidants (e.g., glutathione, urate, vitamin E and vitamin C) or through the capacity of some of these compounds, such as catechins and quercetin, to chelate metallic ions (Fe and Cu, important initiators and catalysts of oxidation reactions) [78]