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M., Hiby, P

Similarly, the first in vivo imaging studies in humans, confirmed an increase in OS and a simultaneous decrease in GSH levels in the motor cortex of patients with ALS (with an age of 65.2 9.4 years, and a mean disease duration of 25.8 17.1 months) compared to the controls [106, 107]

In addition to supporting biosynthesis, NADPH produced in the oxPPP can be either antioxidant or pro-oxidant

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DOI: 10.1104/pp.106.077073 8

compared mononuclear and dinuclear Cu(II) thiosemicarbazone complexes with free thiosemicarbazone ligands and several topoisomerase-II inhibitors, and they revealed that the complexes showed significantly higher growth inhibitory activity against tumor cells, while their IC 50 values were lower [9]