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In both Tetrahymena and Chlamydomonas , glutamylated tubulin is predominantly localized to the axonemal outer doublet MTs, whereas the central pair MTs exhibit little or no detectable modification [51, 52] (Fig

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While these mechanistic insights support the biological plausibility of IFs benefits, most data come from animal studies or short-term human trials, raising questions about their generalizability to long-term clinical outcomes