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Animal species: Cattle, buffalo, horses, pigs

In the context of diabetic myocardium with I/R injury, apelin overexpression exerts cardioprotective effects via suppressing oxidative stress and apoptosis through the Phosphoinositide 3-kinase (PI3K) and p38-MAPK signaling pathways in rats [158]

[DOI] [PMC free article] [PubMed] [Google Scholar] 51.Kumar D Jena GR Ram M Lingaraju MC Singh V Prasad R, et al

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The mucosal protection was fully reversed when the same dose was used daily