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Description
PMID: 313 LiTFuJZengZCohenDLiJChenQet al
Under normal physiological conditions, about 3% of cytosolic glucose is processed via the polyol pathway, however, at higher concentrations of glucose, about 30% of the glucose enters the polyol pathway which makes it important in disposing of the glucose molecules and subsequent conversion to sorbitol [128]
Cytokine Regulation: LL-37 can stimulate the release of pro-inflammatory chemicals (cytokines and chemokines) to launch the defense, but it can also actively inhibit the over-activation of certain Toll-like Receptors (TLRs) by binding to bacterial components like LPS, thus preventing an excessive or damaging inflammatory response (which is key in conditions like sepsis)
Coadministration of warfarin should be monitored carefully
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