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APP is well known for its neuronal development (van der Kant and Goldstein, 2015), and the interaction between 2A -AR and APP may have important clinical implications

Neuropilin, an immunosuppressive surface protein expressed by Tregs that act as VEGF co-receptors, enhances VEGF binding affinity for VEGFRs [88]

Other GLP-1R, GIPR, and glucagon receptor (GCGR) poly-agonists are in development and have been tested in phase 1 and phase 2 clinical trials, including GLP-1R/GCGR agonists, GLP-1R/GLP-2R agonists, and triple GLP-1R/GIPR/GCGR agonists (abstracts presented at the American Diabetes Association Annual Meeting in June, 2022 and (7))

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Then, the images were analyzed using the GLCM algorithm described by the following Eq

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