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Aghili, M., Zahedi, F

The GM and pathogens frequently enhance barrier permeability by modifying the construction and function of tight junctions (TJ)which seal the paracellular spacevia the production of proteases that break TJ proteins or modify the cytoskeleton (44)

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With the identification of key ferroptosis targets (e.g., TRPA1, H3K27 crotonylation), precise interventions using novel small-molecule drugs and biological agents show potential

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