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Peroxynitrite has been shown to cause DNA fragmentation and apoptosis first identified in several cell types such as thymocytes, HL-60 cells, cultured cortical neurons, and PC12 cells

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Additionally, OIPN was not observed in 16 patients

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In this review we will describe the principal ozone pathways as well as anti-inflammatory and immunomodulatory pathways both having cytoprotective effects