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[DOI] [PubMed] [Google Scholar] 53.Higashi Y, et al

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Inflammatory gene expression, including TLR4, NFKB1, TNFA , neutrophil elastase (ELANE), H2A, CASP3 , and CASP7 , was largely unaffected by choline, though a greater reduction in TLR4 expression was observed at higher doses

Our work presents an antimicrobial strategy that harnesses the host-pathogen microenvironment as the intervention target to limit the pathogenesis of infection