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Proteomic analysis of the frontal cortex (area 8) in C9orf72 FTD patients revealed abnormal expression of proteins linked to the synthesis of ROS, suggesting the presence of redox dysregulation in these patients (Andrs-Benito et al., 2019)

Dual strategies for Argonaute2 Slicer-dependent miRNA biogenesis regulate erythropoiesis

designed an RVG29-modified nanomedicine (RVG-nDMC) to deliver 4,4-dimethoxychalcone (DMC) to immune cells and dopaminergic neurons in the brain in order to relieve neuroinflammation and oxidative stress in dopaminergic neurons (Fig

Experimental in vitro models comprise a wide range of cell types and culture procedures, including primary hepatocyte cultures, differentiated hepatic cell lines, stem cell derived hepatocytes, cultured on two- (2D) or three-dimensional (3D) formats, which can significantly influence the outcome of the experiment

doi: 10.1113/JP285104 36 CarpenterGH

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