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Finally, two case reports exist according to which repeatedly administered high doses of insulin resulting in hypoglycemic coma (lowest blood glucose reading 22 mg/dl) were able to bring metastatic cancer in complete remission of at least 1-year duration

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Next to the initial model substrate D1 bearing a 5-aminohexyl moiety, three phosphorothioate oligonucleotides (including multiple LNA modifications) bearing different 5-modifications were investigated

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