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Factors like senescence-associated secretory phenotype (SASP) and microRNAs have been implicated in senescence of pLGG cell lines (58, 59)

(2006) have shown that diallyl disulfide inhibits the production of NO and prostaglandin E2 (PGE2) in lipopolysaccharide (LPS)-stimulated BV2 microglia in a dose-dependent manner

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Therefore, designing large-scale clinical trials to further validate that targeting DTP cells delays drug resistance development and tumor recurrence will be the next major focus in overcoming tumor resistance

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doi: 10.1089/cap.2017.0157