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In addition to the ovaries, steroidogenic enzymes are present in skeletal muscle, enabling the local synthesis of myogenic estrogen

Therefore, cross-reactivity between different types of sulfonamides and sulfonamide-type antibiotics is not clearly demonstrated, and allergic reactions may involve other mechanisms

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IGF-1 is synthesized primarily in the liver and various peripheral tissues in response to growth hormone signalling and exerts its biological effects through binding to the IGF-1 receptor, a transmembrane tyrosine kinase receptor

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