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These include the nitric oxide (NO) signaling system, angiogenic responses via VEGFR2, and antioxidant defense mechanisms involving HO-1 and other key enzymes (Jzwiak et al

This should be taken along with its endothelium maintenance as the follow-up of its cytoprotection capability (Robert, 1979

This may occur due to aging, certain diets, or medications such as Metformin, which is commonly used to treat diabetes