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This decline has been proposed as a contributing factor to impaired wound healing, reduced bone density, and loss of skin elasticity observed in older populations
After the operation, the abdominal cavity was closed by layered suture

We first examined the models by testing their ability to predict the measured flux rates via cross-validation (leaving one out)

It's a less severe concern than, say, copper toxicity, but it's a practical safety issue that must be considered

[DOI] [PubMed] [Google Scholar] 11.van Meer G, Gumbiner B, Simons K

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