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For example, melatonin supplementation has been found to increase the expression of genes such as growth differentiation factor 9 (GDF9), bone morphogenetic protein 15 (BMP15), and pentraxin 3 (PTX3) (77)

Despite the promising findings summarized in this review, several limitations should be acknowledged

In summary, these data show the anzonulin-dependent migration of immune cells from the intestine to the joints during the onset of arthritis

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Kun Ren et al

Local application at the swollen brain implies a direct effect
