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2020 Sep 21;17(1):49

The mitochondrial membrane permeabilization results in the release of the proapoptotic factors from the mitochondrial intermembrane space, cytochrome c [194], AIF [195], and endonuclease G [196], to the cytosol

Additionally, double-stranded RNA-activated protein kinase (PKR) has been identified as a key transducer of inflammatory signals in colonic epithelial cells

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However, the mechanism for induction of ALS neuropathology by statins may be related to the dysregulation of liver X receptor signaling (LXR) signaling in the motor neurons and reduction of cholesterol, which has a neuroprotective effect against ALS neuropathology